Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax3  paired box 3   (Synonyms: Pax-3, Splchl2)
Results	Reference
1	J:187740 Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM, Borycki AG, Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev. 2012 Sep 15;26(18):2103-17
1*	J:81313 Bajanca F, Thorsteinsdottir S, Integrin expression patterns during early limb muscle development in the mouse. Mech Dev. 2002 Dec;119 Suppl 1:S131-4
1*	J:17224 Bober E, Franz T, Arnold HH, Gruss P, Tremblay P, Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development. 1994 Mar;120(3):603-12
1*	J:55780 Borycki AG, Brunk B, Tajbakhsh S, Buckingham M, Chiang C, Emerson CP Jr, Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development. 1999 Sep;126(18):4053-63
1*	J:21616 Braun T, Bober E, Rudnicki MA, Jaenisch R, Arnold HH, MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Development. 1994 Nov;120(11):3083-92
1	J:37117 Burgess R, Rawls A, Brown D, Bradley A, Olson EN, Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature. 1996 Dec 12;384(6609):570-3
1	J:173333 Choi KS, Harfe BD, Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9484-9
1*	J:38385 Conway SJ, Henderson DJ, Copp AJ, Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development. 1997 Jan;124(2):505-14
1*	J:143023 Coumailleau P, Duprez D, Sim1 and Sim2 expression during chick and mouse limb development. Int J Dev Biol. 2009;53(1):149-57
1	J:80024 Delot EC, Bahamonde ME, Zhao M, Lyons KM, BMP signaling is required for septation of the outflow tract of the mammalian heart. Development. 2003 Jan;130(1):209-20
1*	J:18916 Dickinson ME, Krumlauf R, McMahon AP, Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 1994 Jun;120(6):1453-71
1*	J:56236 Dickman ED, Rogers R, Conway SJ, Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: putative roles for Pax3 and PDGFRalpha in rib patterning. Anat Rec. 1999 Jul 1;255(3):353-61
1*	J:49164 Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui CC, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 1998 Jul;125(14):2533-43
1*	J:18227 Goulding M, Lumsden A, Paquette AJ, Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development. 1994 Apr;120(4):957-71
1*	J:19581 Goulding M, Paquette A, Pax genes and neural tube defects in the mouse. Ciba Found Symp. 1994;181:103-13
1*	J:11140 Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P, Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 1991 May;10(5):1135-47
1*	J:47700 Greene ND, Gerrelli D, Van Straaten HW, Copp AJ, Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
1	J:108511 Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development. 2006 May;133(9):1779-87
1	J:119948 Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX, Maire P, Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007 Feb 15;302(2):602-16
1	J:78718 Haase G, Dessaud E, Garces A, de Bovis B, Birling M, Filippi P, Schmalbruch H, Arber S, deLapeyriere O, GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Neuron. 2002 Aug 29;35(5):893-905
1*	J:187741 Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ, Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 2012 Sep 15;26(18):2088-102
1*	J:72468 Kang JS, Mulieri PJ, Hu Y, Taliana L, Krauss RS, BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 2002 Jan 15;21(1-2):114-24
1	J:343326 Kim SE, Chothani PJ, Shaik R, Pollard W, Finnell RH, Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development. Dis Model Mech. 2023 Nov 1;16(11)
1	J:80691 Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG, Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell. 2002 Nov 27;111(5):673-85
1*	J:16332 Koseki H, Wallin J, Wilting J, Mizutani Y, Kispert A, Ebensperger C, Herrmann BG, Christ B, Balling R, A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development. 1993 Nov;119(3):649-60
1*	J:67151 Kruger M, Mennerich D, Fees S, Schafer R, Mundlos S, Braun T, Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development. 2001 Mar;128(5):743-52
1	J:156014 Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME, Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009 Dec;17(6):892-9
1	J:195910 Maier JA, Lo Y, Harfe BD, Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One. 2013;8(1):e55528
1	J:56172 Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A , Wright CV , Rigby PW , Pachnis V, Mox2 is a component of the genetic hierarchy controlling limb muscle development. Nature. 1999 Jul 1;400(6739):69-73
1*	J:47724 McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM, McMahon AP, Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
1*	J:48130 Mennerich D, Schafer K, Braun T, Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb. Mech Dev. 1998 May;73(2):147-58
1	J:185583 Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL, Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
1*	J:103937 Murakami M, Tominaga J, Makita R, Uchijima Y, Kurihara Y, Nakagawa O, Asano T, Kurihara H, Transcriptional activity of Pax3 is co-activated by TAZ. Biochem Biophys Res Commun. 2006 Jan 13;339(2):533-9
1	J:38554 Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K , Mikoshiba K, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol. 1997 Feb 15;182(2):299-313
1	J:127039 Rash BG, Grove EA, Patterning the dorsal telencephalon: a role for sonic hedgehog?. J Neurosci. 2007 Oct 24;27(43):11595-603
1*	J:87381 Schmidtmer J, Engelkamp D, Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns. 2004 Jan;4(1):105-10
1	J:239455 Shin J, Watanabe S, Hoelper S, Kruger M, Kostin S, Poling J, Kubin T, Braun T, BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife. 2016 Dec 01;5:e18351
1*	J:115801 Takeuchi JK, Bruneau BG, Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns. 2007 Jan;7(1-2):51-6
1*	J:330271 Tekko T, Lozovska A, Novoa A, Mallo M, Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos. Dev Dyn. 2022 Oct;251(10):1698-1710
1*	J:100909 Vasyutina E, Stebler J, Brand-Saberi B, Schulz S, Raz E, Birchmeier C, CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005 Sep 15;19(18):2187-98
1	J:323216 Wang YB, Song NN, Zhang L, Ma P, Chen JY, Huang Y, Hu L, Mao B, Ding YQ, Rnf220 is Implicated in the Dorsoventral Patterning of the Hindbrain Neural Tube in Mice. Front Cell Dev Biol. 2022;10:831365
1*	J:34184 Yang XM, Vogan K, Gros P, Park M, Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development. 1996 Jul;122(7):2163-71
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:132613 Zhou HM, Wang J, Rogers R, Conway SJ, Lineage-specific responses to reduced embryonic Pax3 expression levels. Dev Biol. 2008 Mar 15;315(2):369-82